Molecular mechanism of Clofazimine resistance in tuberculosis

Drug resistance which is at present the main impendence to global tuberculosis (TB) control and drug- resistant (DR) activity of Mycobacterium in various strains have become major challenge worldwide. Nowadays, many researchers use different antibiotics for treatment DR-TB are often not well tolerated adequately efficient. A large group study from research published time described a regimen multidrug-resistant (MDR-TB) including Clofazimine (CFZ) as high incidence against MDR-TB; whereas therapeutic ways still limited, strategy repurpose existing anti- mycobacterial agents. CFZ one such drug that has recently devoted interest DR-TB. fat-soluble riminophenazine dye used TB, HIV, leprosy co-infected people shown action MDR TB now recommended by WHO treat agent with “unclear efficacy”. Although mode molecular mechanism yet entirely understood, it been exposed outer membrane its primary site, an extensive number mutant clofazimine found mutations rv0678 be most prominent respiratory chain ion transporters putative targets. This discussed comprehensive report, reactivity CFZ, provides new acuteness into clinical conduct this drug. Key words: Clofazimine, background, action, mechanism.